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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3,   Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: With many superior physical properties over conventional fluids, the low melting point liquid metal materialInspired by the Material Genome Initiative as issued in 2011 by the United States of America, a morespecific and focused project initiative was proposed in this paper—the liquid metal material genome aimedgenome were introduced.The liquid metal material genome proposal as initiated in this paper will accelerate the process of finding

Keywords： liquid metal material genome     energy material     material discovery     advanced material     room-temperature liquid    

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An Intelligent Manufacturing Platform of Polymers: Polymeric Material Genome Engineering Perspective

Liang Gao, Liquan Wang, Jiaping Lin, Lei Du

Engineering 2023, Volume 27, Issue 8,   Pages 31-36 doi: 10.1016/j.eng.2023.01.018

Abstract: Polymeric material genome engineering (PMGE) is becoming a vital platform for the intelligent manufacturing

Keywords： Polymeric materials     Materials genome approach     Machine learning     Property prediction     Rational design    

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomeThe present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 171-180 doi: 10.15302/J-FASE-2019302

Abstract: However, new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjectionRecent advances in precise genome editing technologies, especially clustered regularly interspaced shortnucleases and the state of the art and new insights into practical applications and social acceptance of genomeIt is concluded that the production of gene-edited ruminants is feasible and through improvements in genome

Keywords： bioreactors     breeding     engineered endonucleases     genome editing     ruminants    

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityfor microbial genome.In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing in

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 123-128 doi: 10.15302/J-FASE-2019309

Abstract:

The recent development of genome editing technologies has given researchers unprecedented power toThis mini-review briefly summarizes the development of major genome editing tools, focusing on the application

Keywords： animal model     CRISPR     genome editing     TALEN     ZFN    

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Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 121-122 doi: 10.15302/J-FASE-2019317

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation    

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Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 148-160 doi: 10.15302/J-FASE-2019305

Abstract: Genome editing technology with its ability to directly introduce beneficial sequence variants offersThis review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated

Keywords： animal breeding     cattle     cloning     CRISPR/Cas9     cytoplasmic injection     embryo     genome editing     germline chimaeras    

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 280-289 doi: 10.1007/s11684-013-0265-3

Abstract: Accompanied by a powerful computational data analysis method, new genome-wide screening approaches wereThis review focused on advanced genome-wide screening approaches in fusion gene identification, such

Keywords： gene fusion     cancer     microarray     next-generation sequencing     NanoString nCounter system    

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Genome-edited crops: how to move them from laboratory to market

Kunling CHEN, Caixia GAO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 181-187 doi: 10.15302/J-FASE-2020332

Abstract:

Recent breakthroughs in CRISPR technology allow specific genome manipulation of almost all crops andRationally-based regulation and widespread public acceptance are needed to propel genome-edited crops

Keywords： CRISPR/Cas     genome editing     base editing     precision breeding     regulation    

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Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 77-84 doi: 10.15302/J-FASE-2014010

Abstract: While the differential responses of trees to changes in climatic and environmental conditions have been demonstrated as they age, the underlying mechanisms and age control of tree growth and development are complex and poorly understood particularly at a molecular level. In this paper, we present a transcriptome analysis of , a deciduous conifer that is widely-grown in the northern hemisphere and of significant ecological and economic value. Using high-throughput RNA sequencing, we obtained about 26 million reads from the stems of 1-, 2-, 5-, 10-, 25- and 50-year-old trees. Combining these with the published Roche 454 sequencing reads and the expressed sequence tags (both mainly from embryogenic cell cultures), we assembled 26670549 reads into 146786 transcripts, of which we annotated 79182 to support investigations of the molecular basis of tree aging and adaption, somatic embryogenesis and wood formation. Using these sequences we also identified many single-nucleotide polymorphisms, simple sequence repeats, and insertion and deletion markers to assist breeding and genetic diversity studies of .

Keywords： Larix     transcriptome     age     wood formation     somatic embryogenesis     molecular marker    

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Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 37-45 doi: 10.1007/s11705-017-1618-2

Abstract: Genome engineering tools facilitate rewriting and implementation of engineered DNA sequences.Here we summarize the recent advances in programmable genome engineering tools.

Keywords： CRISPR     genome engineering     synthetic biology     rational design    

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Title Author Date Type Operation

Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Journal Article

An Intelligent Manufacturing Platform of Polymers: Polymeric Material Genome Engineering

Liang Gao, Liquan Wang, Jiaping Lin, Lei Du

Journal Article

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Journal Article

Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Journal Article

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Journal Article

Genome-edited crops: how to move them from laboratory to market

Kunling CHEN, Caixia GAO

Journal Article

Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Journal Article

Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Journal Article